Structural Bioinformatics Scientist - 2024-02/DSN-SBF
Micropep considers all applications, including those from people with disabilities, on an equal basis.
Micropep is building more sustainable agriculture for future generations. We are developing natural crop protection solutions based on the incredible potential of micropeptides, short natural protein molecules that target and regulate plant genes and proteins. We are building the next generation of sustainable solutions for farmers who care about their crops and the future of our planet.
Micropep was founded in 2016 as a spin-off of “LRSV”, a French plant research laboratory from the Centre National de la Recherche Scientifique (CNRS) and Toulouse University, a center of excellence in AgriTech. To date, Micropep has raised nearly $25m from prominent European and US investors and has started its expansion in the USA in 2022.
We are a team of 40+ accomplished and driven individuals from different scientific, technical and business backgrounds. We are united by our desire to leave a positive impact on our planet. Together, we are revolutionizing crop protection with our proprietary micropeptide technology.
Missions
Under the responsibility of the peptide design platform manager, you will be responsible for:
· Designing, developing, building, and maintaining peptide design pipelines, focusing on (but not restricted to) structural and conformational aspects.
· Maintaining a scientific and technical watch and staying abreast of the state-of-the-art in the fields of protein structure prediction and peptide and protein design, from both global research and industrial perspectives.
· Performing structural analyses of systems of interest (detection of pockets, detailed analysis of protein/protein interfaces, of docking pose, etc.)
· Engaging with other peptide and protein design companies to develop partnerships or to conduct joint projects.
Profil
REQUIRED SKILLS 🪴
· Ph.D. in computational chemistry, molecular modeling, structural biology, machine learning, or a related field, with a strong theoretical background as demonstrated by contributions to leading journals; or an equivalent combination of education and experience.
· Hands-on experience designing, training, or utilizing modern deep-learning tools for protein structure prediction, protein modeling or protein design (e.g. AlphaFold, ProteinMPNN, Rosetta tools etc.).
· 3 or more years of experience in protein structure prediction and analysis, including expert knowledge of modern computational chemistry packages and tools, with an emphasis on molecular dynamics, structure prediction and analysis, virtual screening/docking.
· Excellent programming skills.
· High level of self-motivation, intellectual curiosity, and eagerness to thrive in a fast-paced, multidisciplinary, and team-oriented start-up environment.
· Good communication skills, both written and verbal (English mandatory).
· Good organization skills and good optimization of the working environment.
· Ability to manage multiple projects and overlapping deadlines.
· Natural ability for problem-solving.
NICE TO HAVE
· Experience working with flexible systems (linkers, short peptides, IDPs) is highly appreciated.
· Experience using PyMOL or Chimera is preferred.
· Listening comprehension in French is a plus.
CONDITIONS
Temporary contract of 12 months or consulting
Ideally based at Auzeville-Tolosane (close to Toulouse, France)
Starting date: April 2024
Applications with a CV and Cover letter (references optional) must be submitted through Flatchr, with the reference 2024-02/DSN-SBF.